AustralieFrV1, Main, Exploration, bibRecord, 005E09

Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice

Identifieur interne : 005E09 ( Main/Exploration ); précédent : 005E08; suivant : 005E10

Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice

Auteurs : Yuko Katoh-Fukui [Japon] ; Kanako Miyabayashi [Japon] ; Tomoko Komatsu [Japon] ; Akiko Owaki [Japon] ; Takashi Baba [Japon] ; Yuichi Shima [Japon] ; Tomohide Kidokoro [Japon] ; Yoshiakira Kanai [Japon] ; Andreas Schedl [France] ; Dagmar Wilhelm [Australie] ; Peter Koopman [Australie] ; Yasushi Okuno [Japon] ; Ken-Ichirou Morohashi [Japon]

Source :

Endocrinology : (Philadelphia) [ 0013-7227 ] ; 2012.

RBID : Pascal:12-0097235

Descripteurs français

Pascal (Inist)
- Gène, Expression génique, Animal, Souris.

English descriptors

KwdEn :
- Animal, Gene, Gene expression, Mouse.

Abstract

Mice lacking thefunction of the polycomb group protein CBX2 (chromobox homolog 2; also known as M33) show defects in gonadal, adrenal, and splenic development. In particular, XY knockout (KO) mice develop ovaries but not testes, and the gonads are hypoplastic in both sexes. However, how CBX2 regulates development of these tissues remains largely unknown. In the present study, we used microarray, RT-PCR, and immunohistochemical analyses to showthatthe expression of Sry, Sox9, Lhx9, Ad4BP/SF-1, Dax-1, Gata4, Arx, and Dmrt1, genes encoding transcription factors essential for gonadal development, is affected in Cbx2 KO gonads. Male-to-female sex reversal in Cbx2 KO mice was rescued by crossing them with transgenic mice displaying forced expression of Sry or Sox9. However, testes remained hypoplastic in these mice, indicating that the size and the sex of the gonad are determined by different sets of genes. Our study implicates Cbx2 in testis differentiation through regulating Sry gene expression.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001589
to stream PascalFrancis, to step Curation: 004923
to stream PascalFrancis, to step Checkpoint: 001295
to stream Main, to step Merge: 006130
to stream Main, to step Curation: 005E09

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice</title>
<author><name sortKey="Katoh Fukui, Yuko" sort="Katoh Fukui, Yuko" uniqKey="Katoh Fukui Y" first="Yuko" last="Katoh-Fukui">Yuko Katoh-Fukui</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Aging Intervention, National Institute for Longevity Sciences</s1>
<s2>Obu 474-8511</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Obu 474-8511</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miyabayashi, Kanako" sort="Miyabayashi, Kanako" uniqKey="Miyabayashi K" first="Kanako" last="Miyabayashi">Kanako Miyabayashi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Molecular Biology , Graduate School of Medical Sciences, Kyushu University</s1>
<s2>Higashi-ku, Fukuoka 812-8582</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
<orgName type="university">Université de Kyūshū</orgName>
</affiliation>
</author>
<author><name sortKey="Komatsu, Tomoko" sort="Komatsu, Tomoko" uniqKey="Komatsu T" first="Tomoko" last="Komatsu">Tomoko Komatsu</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Veterinary Anatomy, The University of Tokyo</s1>
<s2>Bunkyo-ku, Tokyo 113-8657</s2>
<s3>JPN</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
<settlement type="city">Tokyo</settlement>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Owaki, Akiko" sort="Owaki, Akiko" uniqKey="Owaki A" first="Akiko" last="Owaki">Akiko Owaki</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baba, Takashi" sort="Baba, Takashi" uniqKey="Baba T" first="Takashi" last="Baba">Takashi Baba</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Molecular Biology , Graduate School of Medical Sciences, Kyushu University</s1>
<s2>Higashi-ku, Fukuoka 812-8582</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
<orgName type="university">Université de Kyūshū</orgName>
</affiliation>
</author>
<author><name sortKey="Shima, Yuichi" sort="Shima, Yuichi" uniqKey="Shima Y" first="Yuichi" last="Shima">Yuichi Shima</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Molecular Biology , Graduate School of Medical Sciences, Kyushu University</s1>
<s2>Higashi-ku, Fukuoka 812-8582</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
<orgName type="university">Université de Kyūshū</orgName>
</affiliation>
</author>
<author><name sortKey="Kidokoro, Tomohide" sort="Kidokoro, Tomohide" uniqKey="Kidokoro T" first="Tomohide" last="Kidokoro">Tomohide Kidokoro</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kanai, Yoshiakira" sort="Kanai, Yoshiakira" uniqKey="Kanai Y" first="Yoshiakira" last="Kanai">Yoshiakira Kanai</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Veterinary Anatomy, The University of Tokyo</s1>
<s2>Bunkyo-ku, Tokyo 113-8657</s2>
<s3>JPN</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
<settlement type="city">Tokyo</settlement>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Schedl, Andreas" sort="Schedl, Andreas" uniqKey="Schedl A" first="Andreas" last="Schedl">Andreas Schedl</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institut National de la Santé et de la Recherche Médicale U636 , Centre de Biochimie, Panc Valrose</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>06108 Nice</wicri:noRegion>
<wicri:noRegion>Panc Valrose</wicri:noRegion>
<wicri:noRegion>06108 Nice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wilhelm, Dagmar" sort="Wilhelm, Dagmar" uniqKey="Wilhelm D" first="Dagmar" last="Wilhelm">Dagmar Wilhelm</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute for Molecular Bioscience , The University of Queensland</s1>
<s2>Brisbane, Queensland 4072</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute for Molecular Bioscience , The University of Queensland</s1>
<s2>Brisbane, Queensland 4072</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Okuno, Yasushi" sort="Okuno, Yasushi" uniqKey="Okuno Y" first="Yasushi" last="Okuno">Yasushi Okuno</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University</s1>
<s2>Sakyo-ku, Kyoto 606-8501</s2>
<s3>JPN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
<orgName type="university">Université de Kyoto</orgName>
</affiliation>
</author>
<author><name sortKey="Morohashi, Ken Ichirou" sort="Morohashi, Ken Ichirou" uniqKey="Morohashi K" first="Ken-Ichirou" last="Morohashi">Ken-Ichirou Morohashi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Molecular Biology , Graduate School of Medical Sciences, Kyushu University</s1>
<s2>Higashi-ku, Fukuoka 812-8582</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
<orgName type="university">Université de Kyūshū</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0097235</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0097235 INIST</idno>
<idno type="RBID">Pascal:12-0097235</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001589</idno>
<idno type="wicri:Area/PascalFrancis/Curation">004923</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001295</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001295</idno>
<idno type="wicri:doubleKey">0013-7227:2012:Katoh Fukui Y:cbx:a:polycomb</idno>
<idno type="wicri:Area/Main/Merge">006130</idno>
<idno type="wicri:Area/Main/Curation">005E09</idno>
<idno type="wicri:Area/Main/Exploration">005E09</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice</title>
<author><name sortKey="Katoh Fukui, Yuko" sort="Katoh Fukui, Yuko" uniqKey="Katoh Fukui Y" first="Yuko" last="Katoh-Fukui">Yuko Katoh-Fukui</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Aging Intervention, National Institute for Longevity Sciences</s1>
<s2>Obu 474-8511</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Obu 474-8511</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miyabayashi, Kanako" sort="Miyabayashi, Kanako" uniqKey="Miyabayashi K" first="Kanako" last="Miyabayashi">Kanako Miyabayashi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Molecular Biology , Graduate School of Medical Sciences, Kyushu University</s1>
<s2>Higashi-ku, Fukuoka 812-8582</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
<orgName type="university">Université de Kyūshū</orgName>
</affiliation>
</author>
<author><name sortKey="Komatsu, Tomoko" sort="Komatsu, Tomoko" uniqKey="Komatsu T" first="Tomoko" last="Komatsu">Tomoko Komatsu</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Veterinary Anatomy, The University of Tokyo</s1>
<s2>Bunkyo-ku, Tokyo 113-8657</s2>
<s3>JPN</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
<settlement type="city">Tokyo</settlement>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Owaki, Akiko" sort="Owaki, Akiko" uniqKey="Owaki A" first="Akiko" last="Owaki">Akiko Owaki</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baba, Takashi" sort="Baba, Takashi" uniqKey="Baba T" first="Takashi" last="Baba">Takashi Baba</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Molecular Biology , Graduate School of Medical Sciences, Kyushu University</s1>
<s2>Higashi-ku, Fukuoka 812-8582</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
<orgName type="university">Université de Kyūshū</orgName>
</affiliation>
</author>
<author><name sortKey="Shima, Yuichi" sort="Shima, Yuichi" uniqKey="Shima Y" first="Yuichi" last="Shima">Yuichi Shima</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Molecular Biology , Graduate School of Medical Sciences, Kyushu University</s1>
<s2>Higashi-ku, Fukuoka 812-8582</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
<orgName type="university">Université de Kyūshū</orgName>
</affiliation>
</author>
<author><name sortKey="Kidokoro, Tomohide" sort="Kidokoro, Tomohide" uniqKey="Kidokoro T" first="Tomohide" last="Kidokoro">Tomohide Kidokoro</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kanai, Yoshiakira" sort="Kanai, Yoshiakira" uniqKey="Kanai Y" first="Yoshiakira" last="Kanai">Yoshiakira Kanai</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Veterinary Anatomy, The University of Tokyo</s1>
<s2>Bunkyo-ku, Tokyo 113-8657</s2>
<s3>JPN</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
<settlement type="city">Tokyo</settlement>
</placeName>
<orgName type="university">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Schedl, Andreas" sort="Schedl, Andreas" uniqKey="Schedl A" first="Andreas" last="Schedl">Andreas Schedl</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institut National de la Santé et de la Recherche Médicale U636 , Centre de Biochimie, Panc Valrose</s1>
<s2>06108 Nice</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>06108 Nice</wicri:noRegion>
<wicri:noRegion>Panc Valrose</wicri:noRegion>
<wicri:noRegion>06108 Nice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wilhelm, Dagmar" sort="Wilhelm, Dagmar" uniqKey="Wilhelm D" first="Dagmar" last="Wilhelm">Dagmar Wilhelm</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute for Molecular Bioscience , The University of Queensland</s1>
<s2>Brisbane, Queensland 4072</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute for Molecular Bioscience , The University of Queensland</s1>
<s2>Brisbane, Queensland 4072</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Okuno, Yasushi" sort="Okuno, Yasushi" uniqKey="Okuno Y" first="Yasushi" last="Okuno">Yasushi Okuno</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University</s1>
<s2>Sakyo-ku, Kyoto 606-8501</s2>
<s3>JPN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
<orgName type="university">Université de Kyoto</orgName>
</affiliation>
</author>
<author><name sortKey="Morohashi, Ken Ichirou" sort="Morohashi, Ken Ichirou" uniqKey="Morohashi K" first="Ken-Ichirou" last="Morohashi">Ken-Ichirou Morohashi</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Sex Differentiation , National Institute for Basic Biology</s1>
<s2>Higashiyama, Okazaki 444-8787</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Higashiyama, Okazaki 444-8787</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Molecular Biology , Graduate School of Medical Sciences, Kyushu University</s1>
<s2>Higashi-ku, Fukuoka 812-8582</s2>
<s3>JPN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Fukuoka</settlement>
<region type="province">Kyūshū</region>
<region type="prefecture">Préfecture de Fukuoka</region>
</placeName>
<orgName type="university">Université de Kyūshū</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Endocrinology : (Philadelphia)</title>
<title level="j" type="abbreviated">Endocrinology : (Phila.)</title>
<idno type="ISSN">0013-7227</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Endocrinology : (Philadelphia)</title>
<title level="j" type="abbreviated">Endocrinology : (Phila.)</title>
<idno type="ISSN">0013-7227</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Gene</term>
<term>Gene expression</term>
<term>Mouse</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Gène</term>
<term>Expression génique</term>
<term>Animal</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mice lacking thefunction of the polycomb group protein CBX2 (chromobox homolog 2; also known as M33) show defects in gonadal, adrenal, and splenic development. In particular, XY knockout (KO) mice develop ovaries but not testes, and the gonads are hypoplastic in both sexes. However, how CBX2 regulates development of these tissues remains largely unknown. In the present study, we used microarray, RT-PCR, and immunohistochemical analyses to showthatthe expression of Sry, Sox9, Lhx9, Ad4BP/SF-1, Dax-1, Gata4, Arx, and Dmrt1, genes encoding transcription factors essential for gonadal development, is affected in Cbx2 KO gonads. Male-to-female sex reversal in Cbx2 KO mice was rescued by crossing them with transgenic mice displaying forced expression of Sry or Sox9. However, testes remained hypoplastic in these mice, indicating that the size and the sex of the gonad are determined by different sets of genes. Our study implicates Cbx2 in testis differentiation through regulating Sry gene expression.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Japon</li>
</country>
<region><li>Kyūshū</li>
<li>Préfecture de Fukuoka</li>
<li>Région de Kantō</li>
<li>Région du Kansai</li>
</region>
<settlement><li>Fukuoka</li>
<li>Kyoto</li>
<li>Tokyo</li>
</settlement>
<orgName><li>Université de Kyoto</li>
<li>Université de Kyūshū</li>
<li>Université de Tokyo</li>
</orgName>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Katoh Fukui, Yuko" sort="Katoh Fukui, Yuko" uniqKey="Katoh Fukui Y" first="Yuko" last="Katoh-Fukui">Yuko Katoh-Fukui</name>
</noRegion>
<name sortKey="Baba, Takashi" sort="Baba, Takashi" uniqKey="Baba T" first="Takashi" last="Baba">Takashi Baba</name>
<name sortKey="Kanai, Yoshiakira" sort="Kanai, Yoshiakira" uniqKey="Kanai Y" first="Yoshiakira" last="Kanai">Yoshiakira Kanai</name>
<name sortKey="Katoh Fukui, Yuko" sort="Katoh Fukui, Yuko" uniqKey="Katoh Fukui Y" first="Yuko" last="Katoh-Fukui">Yuko Katoh-Fukui</name>
<name sortKey="Kidokoro, Tomohide" sort="Kidokoro, Tomohide" uniqKey="Kidokoro T" first="Tomohide" last="Kidokoro">Tomohide Kidokoro</name>
<name sortKey="Komatsu, Tomoko" sort="Komatsu, Tomoko" uniqKey="Komatsu T" first="Tomoko" last="Komatsu">Tomoko Komatsu</name>
<name sortKey="Komatsu, Tomoko" sort="Komatsu, Tomoko" uniqKey="Komatsu T" first="Tomoko" last="Komatsu">Tomoko Komatsu</name>
<name sortKey="Miyabayashi, Kanako" sort="Miyabayashi, Kanako" uniqKey="Miyabayashi K" first="Kanako" last="Miyabayashi">Kanako Miyabayashi</name>
<name sortKey="Miyabayashi, Kanako" sort="Miyabayashi, Kanako" uniqKey="Miyabayashi K" first="Kanako" last="Miyabayashi">Kanako Miyabayashi</name>
<name sortKey="Morohashi, Ken Ichirou" sort="Morohashi, Ken Ichirou" uniqKey="Morohashi K" first="Ken-Ichirou" last="Morohashi">Ken-Ichirou Morohashi</name>
<name sortKey="Morohashi, Ken Ichirou" sort="Morohashi, Ken Ichirou" uniqKey="Morohashi K" first="Ken-Ichirou" last="Morohashi">Ken-Ichirou Morohashi</name>
<name sortKey="Okuno, Yasushi" sort="Okuno, Yasushi" uniqKey="Okuno Y" first="Yasushi" last="Okuno">Yasushi Okuno</name>
<name sortKey="Owaki, Akiko" sort="Owaki, Akiko" uniqKey="Owaki A" first="Akiko" last="Owaki">Akiko Owaki</name>
<name sortKey="Shima, Yuichi" sort="Shima, Yuichi" uniqKey="Shima Y" first="Yuichi" last="Shima">Yuichi Shima</name>
<name sortKey="Shima, Yuichi" sort="Shima, Yuichi" uniqKey="Shima Y" first="Yuichi" last="Shima">Yuichi Shima</name>
</country>
<country name="France"><noRegion><name sortKey="Schedl, Andreas" sort="Schedl, Andreas" uniqKey="Schedl A" first="Andreas" last="Schedl">Andreas Schedl</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Wilhelm, Dagmar" sort="Wilhelm, Dagmar" uniqKey="Wilhelm D" first="Dagmar" last="Wilhelm">Dagmar Wilhelm</name>
</noRegion>
<name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005E09 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005E09 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:12-0097235
   |texte=   Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice

Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri